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KMID : 0361020070500030235
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Korean Journal of Otolaryngology - Head and Neck Surgery
2007 Volume.50 No. 3 p.235 ~ p.239
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Association of Epstein-Barr Virus and Head and Neck Cancer in an Endemic Area
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Kim Ah-Young
Roh Jong-Lyel
Kim Jin-Man
Rha Ki-Sang
Park Chan-Il
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Abstract
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Background & Objectives: A number of reports have suggested that Epstein-Barr virus (EBV) is associated with different forms of head and neck cancers (HNC) such as nasopharyngeal carcinoma, NK/T cell lymphoma and Burkitt’s lymphoma. We evaluated the association of EBV with HNC as a causative factor in an endemic area of the virus.
Subjects & Methods: Fresh specimens of HNC were obtained from 72 new patients between August 2003 and January 2005. In situ hybridization for EBER was performed with immunohistochemical staining of p53, Bcl-2 and LMP-1 and serologic tests on anti-viral capsid antigen(VCA) and anti-early antigen (EA)-D. The results of EBV positivity were analyzed according to tumor TNM stages, sites, pathology and smoking status. A correlation between EBV positivity and p53, Bcl-2, LMP-1 positive staining was investigated.
Results: Nine (12%) of the total 72 patients showed EBV positivity of tumor, depending mainly on pathology and sites, but not tumor staging, age, sex or smoking status : NPC (3), NK/T cell lymphoma (5), lymphoephithelial carcinoma of the parotid gland (1). All patients had sero-positivity of anti-VCA IgG but not anti-VCA IgM and anti-EA-D. There was a relationship between the presence of EBV, its oncoprotein (LMP-1) and oncogene (Bcl-2).
Conclusion: Overall, the incidence of EBV positivity of HNC in an endemic area is not significantly different from the prior reports about non-endemic area. The association between EBV and LMP-1 or Bcl-2 may be helpful for understanding the role of viral oncogenes in the HNC.
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KEYWORD
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Epstein-Barr Virus (EBV), Head and Neck Cancer, In situ hybridization, Causative factor, Endemic area
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